Disulfiram-based disulfides as narrow-spectrum antibacterial agents

Axinellamines as Broad-Spectrum Antibacterial Agents: Scalable Synthesis and Biology

Antibiotic-resistant bacteria present an ongoing challenge to both chemists and biologists as they seek novel compounds and modes of action to out-maneuver continually evolving resistance pathways, especially against Gram-negative strains. The dimeric pyrrole-imidazole alkaloids represent a unique marine natural product class with diverse primary biological activity and chemical architecture. T...

Comparative study of plant extracts as broad-spectrum antibacterial agents

Plants with an established history of medicinal uses were tested against various microorganisms in this study. We compared the antibacterial activity of methanol, ethanol, and water extracts of three plant species, including Origanum syriacum, Thymus vulgaris, and Carica papaya, which commonly grow in open habitats or mountainous areas with well-drained soil. The methanol and ethanol extracts o...

Novel Levofloxacin Derivatives as Potent Antibacterial Agents

In this report, a new series of fluoroquinolone agents which was derived from levofloxacin was synthesized and evaluated against Gram-positive (Bacillus subtillis, Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus) and Gram-negative (Esherichio coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens) organisms. The results showed that some of the synth...

Dendrimers as Antibacterial Agents

Pyridinium based amphiphilic hydrogelators as potential antibacterial agents

The numerous applications of hydrogelators have led to rapid expansion of this field. In the present work we report the facile synthesis of amphiphilic hydrogelators having a quaternary pyridinium unit coupled to a hydrophobic long alkyl chain through an amide bond. Different amphiphiles with various hydrophobic chain length and polar head groups were rationally designed and synthesized to deve...